I’ve been using 10 LTSC for a few months now, it works great with the few Windows-only apps I still use. I mainly use it to organize my media library, but it’s not had any problems with the few games I’ve installed with Kernel-level anti-cheat (Destiny 2, Delta Force)
I had to download the Xbox Accessories app to control my Elite controller, but that’s really it.
https://lemm.ee/c/beetlejuicing